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Criteria to prove no significant difference on duplicate sample

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Guest user Created:   Jul 01, 2022 Last commented:   Jul 01, 2022

Criteria to prove no significant difference on duplicate sample

What are the criteria to prove no significant difference on a duplicate sample? Only two values
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ISO 17025 DOCUMENTATION TOOLKIT

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ISO 17025 DOCUMENTATION TOOLKIT

Step-by-step implementation for smaller companies.

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Tracey Evans Jul 01, 2022

I am not informed about the details related to your method so I can only reply with a general comment. It all depends on the of the duplicates, the purpose of your method and the type of test that you perform.  The variation (imprecision) between duplicate results of a sample tested at the same time should be smaller than the longer-term imprecision of your method. What method performance is needed (e.g. sensitivity of calibration curve and long-term precision) must be based on client requirements and capability of the method. For example, the reason for duplicates, and acceptable level of imprecision and target measurement of uncertainty could be influenced by the sample matrix. The target performance either comes from your standard method, sector regulations or is established during method validation. 

I suggest you look at resources related to your sector and basic statistical guidelines. For example, the Eurachem guidelines, available at https://www.eurachem.org/index.php/publications/guides are useful to assist with analytical measurement evaluation.

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Jul 01, 2022

Jul 01, 2022

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